STERNAL MARROW STUDIES IN THYROTOXICOSIS TREATED WITH THIOURACIL AND REVIEW OF LITERATURE REGARDING THIOURACIL EFFECTS ON BLOOD

Sternal marrow studies in thyrotoxicosis treated with thiouracil and review of literature regarding thiouracil effects on blood.

A review of the available literature to date shows 1914 casest of thyrotoxicosis in which thiouracil was employed. This does not include the use of thiourea or other related compounds nor the use of thiouracil in any condition but thyrotoxicosis. Forty-four cases (1.3 per cent) had resulting agranulocytosis, and of these, i per cent) died because of the agranulocytosis. Ninety-three patients pe...

Juvenile thyrotoxicosis treated with thiouracil.

Prepubertal thyrotoxicosis is a condition of some rarity and comparatively few childhood cases have so far been recorded in the literature where the drug thiouracil has been used in treatment. A review of six cases so treated was published by Williams and Janney (1947). The present case provides a suitable example both of the clinical picture and the response to treatment. Atkinson (1938) in a ...

Morphological examination of the blood and sternal marrow on nine patients treated with thiouracil.

By CARL J. GESSLER, M.D. B ECAUSE of the current interest in agranulocytosis following thiouracil administration it was determined to study the blood and bone marrow in a series of 9 patients under treatment with this drug for hyperthyroidism. It is of interest that before treatment was instituted the total leukocyte count in 4 of the 9 cases was less than 4,000 per cu. mm., with a correspondin...

Thiouracil in Thyrotoxicosis

Some Observations on Thiouracil Neutropenia, with Special Reference to the Sternal Marrow.